Influence of TP53 gene mutations and their allelic status in myelodysplastic syndromes with isolated 5q deletion.

doi:10.1182/blood.2024023840

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Article

Influence of TP53 gene mutations and their allelic status in myelodysplastic syndromes with isolated 5q deletion.

Blood - 17 Oct 2024

Montoro Maria Julia, Palomo Laura, Haferlach Claudia, Acha Pamela, Chan Onyee, Navarro Víctor, Kubota Yasuo, Schulz Felicitas Isabel, Meggendorfer Manja, Briski Robert, Al Ali Najla, Xicoy Blanca, López-Cadenas Félix, Bosch Francesc, González Teresa, Eder Lea Naomi, Jerez Andrés, Wang Yu-Hung, Campagna Alessia, Santini Valeria, Bernal Del Castillo Teresa, Such Esperanza, Tien Hwei-Fang, Diaz Varela Nicolás, Platzbecker Uwe, Haase Detlef, Díez-Campelo María, Della Porta Matteo, Garcia-Manero Guillermo, Wiseman Daniel H, Germing Ulrich, Maciejewski Jaroslaw P, Komrokji Rami S, Sole Francesc, Haferlach Torsten, Valcárcel David

Abstract excerpt

ABSTRACT: Mutations in the TP53 gene, particularly multihit alterations, have been associated with unfavorable clinical features and prognosis in patients diagnosed with myelodysplastic syndrome (MDS). Despite this, the role of TP53 gene aberrations in MDS with isolated deletion of chromosome 5 [MDS-del(5q)] remains unclear. This study aimed to assess the impact of TP53 gene mutations and their allelic state in...

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Identifiers

PMID: 39074355
DOI: 10.1182/blood.2024023840

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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