Article
TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis.
British journal of haematology - 1 Mar 2013
Kulasekararaj Austin G, Smith Alexander E, Mian Syed A, Mohamedali Azim M, Krishnamurthy Pramila, Lea Nicholas C, Gäken Joop, Pennaneach Coralie, Ireland Robin, Czepulkowski Barbara, Pomplun Sabine, Marsh Judith C, Mufti Ghulam J
Abstract excerpt
This study aimed to determine the incidence/prognostic impact of TP53 mutation in 318 myelodysplastic syndrome (MDS) patients, and to correlate the changes to cytogenetics, single nucleotide polymorphism array karyotyping and clinical outcome. The median age was 65 years (17-89 years) and median follow-up was 45 months [95% confidence interval (CI) 27-62 months]. TP53 mutations occurred in 30 (9.4%) patients,...
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