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Article

TP53 in Myelodysplastic Syndromes: Recent Biological and Clinical Findings.

International journal of molecular sciences - 13 May 2020

Cumbo Cosimo, Tota Giuseppina, Anelli Luisa, Zagaria Antonella, Specchia Giorgina, Albano Francesco

Abstract excerpt

TP53 dysregulation plays a pivotal role in the molecular pathogenesis of myelodysplastic syndromes (MDS), identifying a subgroup of patients with peculiar features. In this review we report the recent biological and clinical findings of TP53-mutated MDS, focusing on the molecular pathways activation and on its impact on the cellular physiology. In MDS, TP53 mutational status is deeply associated with del(5q)...

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Identifiers

PMID: 32414002
DOI: 10.3390/ijms21103432
PMCID: PMC7279310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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