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Impact of IL-6 and IL-10 genotypes on tacrolimus dose requirements in kidney transplant recipients: Monte Carlo analysis.

Pharmacogenomics - 1 Jan 2024

Stefanović Nikola, Danković Katarina, Cvetković Tatjana, Vujić Stevan, Pavlović Ivan, Jevtović-Stoimenov Tatjana, Mitić Branka, Veličković-Radovanović Radmila

Abstract excerpt

Introduction: IL-6 and IL-10 may affect the activity of cytochrome P450 (CYP) 3A enzymes involved in tacrolimus (Tac) metabolism. Moreover, the effect of IL-6 and IL-10 on Tac pharmacokinetics may differ with respect to the genetic variations in their genes.Aim: To examine the influence of IL-6 and IL-10 gene polymorphisms on Tac dose requirements and exposure over a 5-year period following kidney...

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Identifiers

PMID: 39069949
DOI: 10.1080/14622416.2024.2379227
PMCID: PMC11404698

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