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Potential influence of interleukin-6 -174G/C gene polymorphism on kidney graft function and tacrolimus dose requirements: five-year follow-up.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Oct 2024

Danković Katarina, Stefanović Nikola, Cvetković Tatjana, Vujić Stevan, Jović Maša, Mitić Branka, Veličković-Radovanović Radmila

Abstract excerpt

1. INTRODUCTION: The study aimed to investigate the influence of interleukin (IL)-6 -174 G/C gene polymorphism on graft function (defined as estimated glomerular filtration rate, eGFR), as well as on the tacrolimus (Tac) pharmacokinetics during the five years after kidney transplantation. 2. METHODS: The study included 115 Caucasian kidney transplant recipients on Tac-based immunosuppression. The patients were...

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PMID: 39535282
DOI: 10.1080/00498254.2024.2427032

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