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The effect of genetic variations for interleukin-10 (IL-10) on the efficacy of immunosuppressive therapy in patients after kidney transplantation.

International immunopharmacology - 1 Dec 2020

Bogacz Anna, Polaszewska Anna, Bartkowiak-Wieczorek Joanna, Tejchman Karol, Dziewanowski Krzysztof, Ostrowski Marek, Czerny Bogusław, Grześkowiak Edmund, Sieńko Magdalena, Machaliński Bogusław, Sieńko Jerzy, Kotowski Maciej

Abstract excerpt

Kidney transplantation is the target method of treating chronic kidney disorders. It improves the comfort of patient life by eliminating the need for repeated dialysis. The aim of the study was to examine the correlation between tacrolimus (TAC) dose and genetic variation for interleukin-10 (IL-10) and its effect on the therapeutic outcome. In addition, the correlations between the IL-10 polymorphism andthe...

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Identifiers

PMID: 33039969
DOI: 10.1016/j.intimp.2020.107059

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