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Article

Association of Glutathione Transferase M1, T1, P1 and A1 Gene Polymorphism and Susceptibility to IgA Vasculitis.

International journal of molecular sciences - 16 Jul 2024

Juras Ana, Crkvenac Gornik Kristina, Held Martina, Sestan Mario, Turudic Daniel, Sapina Matej, Srsen Sasa, Huljev Frkovic Sanda, Frkovic Marijan, Gagro Alenka, Jelusic Marija

Abstract excerpt

Endothelial cell injury is a hallmark of IgA vasculitis (IgAV), possibly associated with various factors, including oxidative stress. Certain single nucleotide polymorphisms (SNPs) of glutathione S-transferases (GST) genes have been shown to increase susceptibility to oxidative stress. The objective of our study was to evaluate the gene polymorphisms of GSTM1, GSTT1, GSTP1, and GSTA1 in patients with IgAV. DNA...

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Identifiers

PMID: 39063019
DOI: 10.3390/ijms25147777
PMCID: PMC11277070

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