IgA vasculitis sibling clustering: From HLA-DRB1 genetic burden to nephritis risk stratification.

Abstract excerpt

IgA vasculitis (IgAV) is the most common systemic small-vessel vasculitis in childhood, with an annual incidence of 3 to 26.7 per 100,000 children. Although it is predominantly sporadic, its 1.9% familial clustering rate and significant tendency for sibling comorbidity suggest a non-random pathogenesis. Multicohort GWAS data confirm that HLA-DRB1*01 and HLA-DRB1*11 are common genetic risk loci across ethnic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genetic Predisposition to Disease
• Share to Genome-Wide Association Study