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Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies.

Andrology - 1 Jul 2025

Cavarocchi Emma, Drouault Maëva, Ribeiro Joao C, Simon Violaine, Whitfield Marjorie, Touré Aminata

Abstract excerpt

BACKGROUND: In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and motility. Primary motility of the sperm cells is acquired during their...

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Asthenozoospermia
Mutation
Plant Reproductive Biology
Reproductive biology and impacts on aquatic species
Sperm and Testicular Function

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PMID: 39748639
DOI: 10.1111/andr.13828
PMCID: PMC12183016

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