Article
CFAP74 Variants Could Cause Male Infertility With the Asthenoteratozoospermia Phenotype.
Annals of human genetics - 1 May 2026
Chen Guoyong, Wang Yulin, Kang Jingyi, Mei Xiaoyan, Zhang Zhedan, Zhang Yan, Lu Jun, Liu Yun, Lan Fenghua, Huang Wujian, Zhang Duo
Abstract excerpt
BACKGROUND: Severe asthenozoospermia, particularly when associated with multiple morphological abnormalities of the flagella (MMAF), represents a genetically influenced disorder, although the precise pathogenic mechanisms remain incompletely characterized. METHODS: In this study, whole-exome sequencing (WES) was performed for 44 asthenoteratozoospermia patients, and 11 pathogenic genes were detected in 20 of them...
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