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Article

Homozygous variant in DRC3 (LRRC48) gene causes asthenozoospermia and male infertility.

Journal of human genetics - 1 Aug 2024

Qin Jiao, Wang Jinyu, Chen Jianhai, Xu Jinyan, Liu Shanling, Deng Dong, Li Fuping

Abstract excerpt

Human infertility affects 10-15% of couples. Asthenozoospermia accounts for 18% of men with infertility and is a common male infertility phenotype. The nexin-dynein regulatory complex (N-DRC) is a large protein complex in the sperm flagellum that connects adjacent doublets of microtubules. Defects in the N-DRC can disrupt cilia/flagellum movement, resulting in primary ciliary dyskinesia and male infertility....

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PMID: 38769386
DOI: 10.1038/s10038-024-01253-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Homozygous variant in DRC3 (LRRC48) gene causes asthenozoospermia and male infertility.PMID 38769386Read ↗

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LRRC23 deficiency causes male infertility with idiopathic asthenozoospermia by disrupting the assembly of radial spokesSemantic proximity Read ↗

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