Article
Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jul 2024
Wang Yiying, Le Yuan, Harris Kelly L, Chen Ying, Li Xilin, Faske Jennifer, Wynne Rebecca A, Mittelstaedt Roberta A, Cao Xuefei, Miranda-Colon Jaime, Elkins Lana, Muskhelishvili Levan, Davis Kelly, Mei Nan, Sun Wei, Robison Timothy W, Heflich Robert H, Parsons Barbara L
Abstract excerpt
The human in vitro organotypic air-liquid-interface (ALI) airway tissue model is structurally and functionally similar to the human large airway epithelium and, as a result, is being used increasingly for studying the toxicity of inhaled substances. Our previous research demonstrated that DNA damage and mutagenesis can be detected in human airway tissue models under conditions used to assess general and...
Topics
- Humans
- Ethyl Methanesulfonate
- Mutation
- DNA Damage
- Mutagenesis
- Mutagens
- Bronchi