Article
In Vivo Evolution of a Klebsiella pneumoniae Capsule Defect With wcaJ Mutation Promotes Complement-Mediated Opsonophagocytosis During Recurrent Infection.
The Journal of infectious diseases - 25 Jul 2024
Bain William, Ahn Brian, Peñaloza Hernán F, McElheny Christi L, Tolman Nathanial, van der Geest Rick, Gonzalez-Ferrer Shekina, Chen Nathalie, An Xiaojing, Hosuru Ria, Tabary Mohammadreza, Papke Erin, Kohli Naina, Farooq Nauman, Bachman William, Olonisakin Tolani F, Xiong Zeyu, Griffith Marissa P, Sullivan Mara, Franks Jonathan, Mustapha Mustapha M, Iovleva Alina, Suber Tomeka, Shanks Robert Q, Ferreira Viviana P, Stolz Donna B, Van Tyne Daria, Doi Yohei, Lee Janet S
Abstract excerpt
BACKGROUND: Klebsiella pneumoniae carbapenemase-producing K pneumoniae (KPC-Kp) bloodstream infections are associated with high mortality. We studied clinical bloodstream KPC-Kp isolates to investigate mechanisms of resistance to complement, a key host defense against bloodstream infection. METHODS: We tested growth of KPC-Kp isolates in human serum. In serial isolates from a single patient, we performed whole...
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