Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Klebsiella pneumoniae evolution in the gut leads to spontaneous capsule loss and decreased virulence potential

31 Mar 2025

Abstract excerpt

ABSTRACT Klebsiella pneumoniae ( Kp ) is an opportunistic pathogen that poses a major threat in healthcare settings. The gut is a primary Kp reservoir in hospitalized patients, and colonization is a major risk factor for Kp infection. The stability of virulence determinants such as capsule and lipopolysaccharide during gut colonization is largely unexplored. In a murine gut colonization model, we demonstrated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotic Resistance in Bacteria
Share to Escherichia coli research studies
Share to Mycobacterium research and diagnosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40162782
DOI: 10.1128/mbio.02362-24

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Klebsiella pneumoniae evolution in the gut leads to spontaneous capsule loss and decreased virulence potentialPMID 40162782Read ↗

Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae.Semantic proximity Read ↗

In vivo evolution of a Klebsiella pneumoniae capsule defect promotes complement-mediated opsono-phagocytosis and persistence during recurrent infectionSemantic proximity Read ↗

The intersection of capsule gene expression, hypermucoviscosity and hypervirulence in Klebsiella pneumoniae.Semantic proximity Read ↗

Hypermucoviscosity in Klebsiella pneumoniae: manifestation, regulation, and roles in pathogenesis.Semantic proximity Read ↗

Genome-wide screens reveal shared and strain-specific genes that facilitate enteric colonization by Klebsiella pneumoniaeSemantic proximity Read ↗

Virulence Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Strains from Patients with Necrotizing Skin and Soft Tissue Infections.Semantic proximity Read ↗

Decoding Hypervirulence in Carbapenem-Resistant Klebsiella pneumoniae: Genomic and Phenotypic Profiling Reveals Capsular Polysaccharide as a Key Driver of Pathogenicity.Semantic proximity Read ↗

Adaptive evolution of carbapenem-resistant hypervirulent Klebsiella pneumoniae in the urinary tract of a single patientSemantic proximity Read ↗

Genome-wide screens reveal shared and strain-specific genes that facilitate enteric colonization by <i>Klebsiella pneumoniae</i>Semantic proximity Read ↗

Low prevalence of rmpA and high tendency of rmpA mutation correspond to low virulence of extended spectrum β-lactamase-producing Klebsiella pneumoniae isolates.Semantic proximity Read ↗

In Vivo Evolution of a Klebsiella pneumoniae Capsule Defect With wcaJ Mutation Promotes Complement-Mediated Opsonophagocytosis During Recurrent Infection.Semantic proximity Read ↗

The acquisition of <i>rmpADC</i> can increase virulence of classical <i>Klebsiella pneumoniae</i> in the absence of other hypervirulence-associated genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.