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Article

Wzc mutation enhances virulence in CRKP ST11-KL64 via complement-mediated lysis and lipopolysaccharide release.

Microbiology spectrum - 7 Apr 2026

Yan Huanhuan, Dai Yufeng, Ye Kun, Zhao Qiang, Guo Na, Wang Lifeng, Yang Jiyong

Abstract excerpt

Carbapenem-resistant Klebsiella pneumoniae (CRKP) ST11-KL64 has emerged as the dominant subclone in China. Mutations in Wzc confer a hypermucoviscous (HMV) phenotype and enhanced virulence, but how these mutations regulate capsular polysaccharide (CPS) architecture, whether they alter virulence traits, and the mechanisms and consequences of these alterations remain unclear. We found that the WzcY572D mutation in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41757897
DOI: 10.1128/spectrum.02847-25
PMCID: PMC13055261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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