Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Jan 2023

He Jintao, Shi Qiucheng, Chen Zhifu, Zhang Wang, Lan Peng, Xu Qingye, Hu Huangdu, Chen Qiong, Fan Jianzhong, Jiang Yan, Loh Belinda, Leptihn Sebastian, Zou Quanming, Zhang Jinyong, Yu Yunsong, Hua Xiaoting

Abstract excerpt

AIMS: To investigate the in vivo evolution of the mucoid-phenotype of ST11-KL64 carbapenem-resistant Klebsiella pneumoniae (CRKP) isolated from the same patients and gain insights into diverse evolution and biology of these strains. METHODS: Whole genome sequencing and bioinformatic analysis were used to determine the mutation involved in the mucoid phenotype of ST11-KL64 CRKP. Gene knockout, bacterial morphology...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Antibiotic Resistance in Bacteria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carbapenems

Share to Klebsiella Infections

Share to Klebsiella pneumoniae

Share to Multilocus Sequence Typing

Share to Mutation

Share to Virulence

Source

Identifiers

PMID: 36427451
DOI: 10.1016/j.drup.2022.100891

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae.PMID 36427451Read ↗

Wzc mutation enhances virulence in CRKP ST11-KL64 via complement-mediated lysis and lipopolysaccharide release.Semantic proximity Read ↗

Adaptive attenuation of virulence mediated by Wzc mutation in ST11-KL47 Carbapenem-resistant Klebsiella pneumoniaSemantic proximity Read ↗

Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae.Semantic proximity Read ↗

Hypermucoviscosity in Klebsiella pneumoniae: manifestation, regulation, and roles in pathogenesis.Semantic proximity Read ↗

Adaptive evolution of carbapenem-resistant hypervirulent Klebsiella pneumoniae in the urinary tract of a single patientSemantic proximity Read ↗

The wzc mutation mediates virulence changes in K1-type Klebsiella pneumoniae within the same patientSemantic proximity Read ↗

Genetic, virulence, and antimicrobial resistance characteristics associated with distinct morphotypes in ST11 carbapenem-resistant Klebsiella pneumoniae.Semantic proximity Read ↗

In vivo evolution to hypermucoviscosity and ceftazidime/avibactam resistance in a liver abscess caused by Klebsiella pneumoniae sequence type 512.Semantic proximity Read ↗

The Emergence of Novel Sequence Type Strains Reveals an Evolutionary Process of Intraspecies Clone Shifting in ICU-Spreading Carbapenem-Resistant Klebsiella pneumoniaeSemantic proximity Read ↗

Co-occurrence of ST412 <i>Klebsiella pneumoniae</i> isolates with hypermucoviscous and no-mucoviscous phenotypes in a short-term hospitalized patientSemantic proximity Read ↗

Co-occurrence of ST412 Klebsiella pneumoniae isolates with hypermucoviscous and non-mucoviscous phenotypes in a short-term hospitalized patient.Semantic proximity Read ↗

In-host evolution of classic to convergent <i>Klebsiella pneumoniae</i> sequence type 147 isolates and impact of associated capsular changes on different morphotypesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.