Genetic variation in NOTCH1 is associated with overweight and obesity in Brazilian elderly.

doi:10.1038/s41598-024-65771-1

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Article

Genetic variation in NOTCH1 is associated with overweight and obesity in Brazilian elderly.

Scientific reports - 24 Jul 2024

Silva Barcelos Estevão Carlos, Naslavsky Michel Satya, Fernandes Izadora Silveira, Scliar Marilia Oliveira, Yamamoto Guilherme Lopes, Wang Jaqueline Yu Ting, Bride Laís, de Sousa Valdemir Pereira, Pimassoni Lucia Helena Sagrillo, Sportoletti Paolo, de Paula Flavia, von Zeidler Sandra Ventorin, Duarte Yeda Aparecida Oliveira, Passos-Bueno Maria Rita, Zatz Mayana, Errera Flávia Imbroisi Valle

Abstract excerpt

Excessive weight (overweight and obesity) is a common disorder involving genetic and environmental factors, associated with cardiovascular diseases, type-2 diabetes, and others. NOTCH1 is critical for the maintenance of stem cells and adult tissues, being reported as a key player in metabolism and adipogenesis in animals. Thus, we test the hypothesis that NOTCH1 Single Nucleotide Polymorphisms (SNPs) are...

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Identifiers

PMID: 39048597
DOI: 10.1038/s41598-024-65771-1
PMCID: PMC11269636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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