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Article

Sp100 colocalizes with HPV replication foci and restricts the productive stage of the infectious cycle

2 Oct 2017

Abstract excerpt

We have shown previously that Sp100 (a component of the ND10 nuclear body) represses transcription, replication and establishment of incoming human papillomavirus (HPV) DNA in the early stages of infection. In this follow up study, we show that Sp100 does not substantially regulate viral infection in the maintenance phase, however at late stages of infection Sp100 interacts with amplifying viral genomes to...

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PMID: 28968443
DOI: 10.1371/journal.ppat.1006660

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