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Article

Frataxin Loss Promotes Angiotensin II-Induced Endothelial-to-Mesenchymal Transition.

Journal of the American Heart Association - 6 Aug 2024

Guo Yuetong, Cheng Xingyi, Huang Chenglin, Gao Jing, Shen Weili

Abstract excerpt

BACKGROUND: The metabolic flexibility of endothelial cells is linked to their phenotypic plasticity. Frataxin is critical in determining the iron metabolism and fate of endothelial cells. This study aimed to investigate frataxin-mediated metabolic remodeling during the endothelial-to-mesenchymal transition (EndoMT). METHODS AND RESULTS: Endothelial cell-specific frataxin knockout and frataxin mutation mice were...

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Identifiers

PMID: 39023059
DOI: 10.1161/JAHA.124.034316
PMCID: PMC11964068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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