Article

Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function

2022-08-23

Abstract excerpt

Deficiency of iron-sulfur (Fe-S) clusters promotes metabolic rewiring of the endothelium and the development of pulmonary hypertension (PH) in vivo . Joining a growing number of Fe-S biogenesis proteins critical to pulmonary endothelial function, recent data highlighted that frataxin (FXN) reduction drives Fe-S-dependent genotoxic stress and senescence across multiple types of pulmonary vascular disease. Trinucle...

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Literature Corpus work: 6b9fd2ba-9ceb-50ce-bda3-c4b03b680325
DOI: 10.1101/2022.08.22.504849

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