Article
Functional ex vivo DNA fibre assay to measure replication dynamics in breast cancer tissue.
The Journal of pathology - 1 Sept 2024
Chen Mengting, van den Tempel Nathalie, Bhattacharya Arkajyoti, Yu Shibo, Rutgers Bea, Fehrmann Rudolf Sn, de Haas Sander, van der Vegt Bert, van Vugt Marcel Atm
Abstract excerpt
Replication stress (RS) is a key trait of cancer cells, and a potential actionable target in cancer treatment. Accurate methods to measure RS in tumour samples are currently lacking. DNA fibre analysis has been used as a common technique to measure RS in cell lines. Here, we investigated DNA fibre analysis on fresh breast cancer specimens and correlated DNA replication kinetics to known RS markers and genomic...
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