Article
DHX9 SUMOylation is required for the suppression of R-loop-associated genome instability.
Nature communications - 17 Jul 2024
Yang Bing-Ze, Liu Mei-Yin, Chiu Kuan-Lin, Chien Yuh-Ling, Cheng Ching-An, Chen Yu-Lin, Tsui Li-Yu, Lin Keng-Ru, Chu Hsueh-Ping Catherine, Wu Ching-Shyi Peter
Abstract excerpt
RNA helicase DHX9 is essential for genome stability by resolving aberrant R-loops. However, its regulatory mechanisms remain unclear. Here we show that SUMOylation at lysine 120 (K120) is crucial for DHX9 function. Preventing SUMOylation at K120 leads to R-loop dysregulation, increased DNA damage, and cell death. Cells expressing DHX9 K120R mutant which cannot be SUMOylated are more sensitive to genotoxic agents...
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