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RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors

1 Feb 2021

Abstract excerpt

Germline mutations in BRCA1 and BRCA2 (BRCA1/2) genes considerably increase breast and ovarian cancer risk. Given that tumors with these mutations have elevated genomic instability, they exhibit relative vulnerability to certain chemotherapies and targeted treatments based on poly (ADP-ribose) polymerase (PARP) inhibition. However, the molecular mechanisms that influence cancer risk and therapeutic benefit or...

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PMID: 33529165
DOI: 10.1172/jci140105

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RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumorsPMID 33529165Read ↗

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