Article
Pooled Amplicon Deep Sequencing of Candidate Plasmodium falciparum Transmission-Blocking Vaccine Antigens.
The American journal of tropical medicine and hygiene - 1 Jan 2016
Juliano Jonathan J, Parobek Christian M, Brazeau Nicholas F, Ngasala Billy, Randrianarivelojosia Milijaona, Lon Chanthap, Mwandagalirwa Kashamuka, Tshefu Antoinette, Dhar Ravi, Das Bidyut K, Hoffman Irving, Martinson Francis, Mårtensson Andreas, Saunders David L, Kumar Nirbhay, Meshnick Steven R
Abstract excerpt
Polymorphisms within Plasmodium falciparum vaccine candidate antigens have the potential to compromise vaccine efficacy. Understanding the allele frequencies of polymorphisms in critical binding regions of antigens can help in the designing of strain-transcendent vaccines. Here, we adopt a pooled deep-sequencing approach, originally designed to study P. falciparum drug resistance mutations, to study the diversity...
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