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Article

Nonadditive Effects of Common Genetic Variants Have a Negligent Contribution to Cancer Heritability.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 2 Oct 2024

Hammermeister Suger Austin, Harrison Tabitha A, Henning Barbara, Turman Constance, Kraft Peter, Lindström Sara

Abstract excerpt

BACKGROUND: Contribution of dominance effects to cancer heritability is unknown. We leveraged existing genome-wide association data for seven cancers to estimate the contribution of dominance effects to the heritability of individual cancer types. METHODS: We estimated the proportion of phenotypic variation caused by dominance genetic effects using genome-wide association data for seven cancers (breast,...

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PMID: 39018351
DOI: 10.1158/1055-9965.EPI-24-0496
PMCID: PMC11446654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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