Article
Most common 'sporadic' cancers have a significant germline genetic component.
Human molecular genetics - 15 Nov 2014
Lu Yi, Ek Weronica E, Whiteman David, Vaughan Thomas L, Spurdle Amanda B, Easton Douglas F, Pharoah Paul D, Thompson Deborah J, Dunning Alison M, Hayward Nicholas K, Chenevix-Trench Georgia, Macgregor Stuart
Abstract excerpt
Common cancers have been demarcated into 'hereditary' or 'sporadic' ('non-hereditary') types historically. Such distinctions initially arose from work identifying rare, highly penetrant germline mutations causing 'hereditary' cancer. While rare mutations are important in particular families, most cases in the general population are 'sporadic'. Twin studies have suggested that many 'sporadic' cancers show little...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.