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Article

Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation.

NPJ systems biology and applications - 16 Jul 2024

Trogdon Michael, Abbott Kodye, Arang Nadia, Lande Kathryn, Kaur Navneet, Tong Melinda, Bakhoum Mathieu, Gutkind J Silvio, Stites Edward C

Abstract excerpt

Mathematical models of biochemical reaction networks are an important and emerging tool for the study of cell signaling networks involved in disease processes. One promising potential application of such mathematical models is the study of how disease-causing mutations promote the signaling phenotype that contributes to the disease. It is commonly assumed that one must have a thorough characterization of the...

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PMID: 39013872
DOI: 10.1038/s41540-024-00400-1
PMCID: PMC11252164

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