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Article

What lies beneath: looking beyond tumor genetics shows the complexity of signaling networks underlying drug sensitivity.

Science signaling - 24 Sept 2013

Quaranta Vito, Tyson Darren R

Abstract excerpt

The identification of "driver mutations" in cancers initiated rapid development of targeted drugs for the clinic. Despite promising outcomes initially in patients, the ultimate success of oncogene-targeted drugs has been hampered by the redundancy and remarkable complexity of cellular signaling pathways. Two studies in Science Signaling show that understanding these intricate networks and considering them during...

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Identifiers

PMID: 24065144
DOI: 10.1126/scisignal.2004715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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