Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanistic modeling to investigate signaling by oncogenic Ras mutants.

Wiley interdisciplinary reviews. Systems biology and medicine - 1 Jan 2000

Stites Edward C, Ravichandran Kodi S

Abstract excerpt

Mathematical models based on biochemical reaction mechanisms can be a powerful complement to experimental investigations of cell signaling networks. In principle, such models have the potential to find the behaviors that result from well-understood component interactions and their measurable prop...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Communication
Share to Models, Genetic
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Share to Oncogenes

Share to ras Proteins

Share to Signal Transduction

Source

Identifiers

PMID: 21766467
DOI: 10.1002/wsbm.156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21766467-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanistic modeling to investigate signaling by oncogenic Ras mutants.PMID 21766467Read ↗

Mathematical investigation of how oncogenic ras mutants promote ras signaling.Semantic proximity Read ↗

New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling.Semantic proximity Read ↗

Chemical kinetic mechanistic models to investigate cancer biology and impact cancer medicine.Semantic proximity Read ↗

Mathematical Modeling to Study KRAS Mutant-Specific Responses to Pathway Inhibition.Semantic proximity Read ↗

Computational Random Mutagenesis to Investigate RAS Mutant Signaling.Semantic proximity Read ↗

Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation.Semantic proximity Read ↗

A quantitative systems pharmacology analysis of KRAS G12C covalent inhibitorsSemantic proximity Read ↗

A computational panel of pathological RAS mutants with implications for personalized medicine and genetic medicineSemantic proximity Read ↗

A systems mechanism for KRAS mutant allele–specific responses to targeted therapySemantic proximity Read ↗

Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling.Semantic proximity Read ↗

Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathwaySemantic proximity Read ↗

Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.