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Article

Renal cystic disease in tuberous sclerosis complex.

Experimental biology and medicine (Maywood, N.J.) - 1 Oct 2021

Kumar Prashant, Zadjali Fahad, Yao Ying, Bissler John J

Abstract excerpt

Tuberous sclerosis complex (TSC) is associated with TSC1 or TSC2 gene mutations resulting in hyperactivation of the mTORC1 pathway. This mTORC1 activation is associated with abnormal tissue development and proliferation such that in the kidney there are both solid tumors and cystic lesions. This review summarizes recent advances in tuberous sclerosis complex nephrology and focuses on the genetics and cell biology...

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Source

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Identifiers

PMID: 34488473
DOI: 10.1177/15353702211038378
PMCID: PMC8524767

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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