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Article

A comprehensive analysis of germline predisposition to early-onset ovarian cancer.

Scientific reports - 13 Jul 2024

Horackova Klara, Zemankova Petra, Nehasil Petr, Vocka Michal, Hovhannisyan Milena, Matejkova Katerina, Janatova Marketa, Cerna Marta, Kleiblova Petra, Jelinkova Sandra, Stastna Barbora, Just Pavel, Dolezalova Tatana, Nemcova Barbora, Urbanova Marketa, Koudova Monika, Hazova Jana, Machackova Eva, Foretova Lenka, Stranecky Viktor, Zikan Michal, Kleibl Zdenek, Soukupova Jana

Abstract excerpt

The subset of ovarian cancer (OC) diagnosed ≤ 30yo represents a distinct subgroup exhibiting disparities from late-onset OC in many aspects, including indefinite germline cancer predisposition. We performed DNA/RNA-WES with HLA-typing, PRS assessment and survival analysis in 123 early-onset OC-patients compared to histology/stage-matched late-onset and unselected OC-patients, and population-matched controls. Only...

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Identifiers

PMID: 39003285
DOI: 10.1038/s41598-024-66324-2
PMCID: PMC11246516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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