Article
Common Genetic Variation and Susceptibility to Ovarian Cancer: Current Insights and Future Directions.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2018
Kar Siddhartha P, Berchuck Andrew, Gayther Simon A, Goode Ellen L, Moysich Kirsten B, Pearce Celeste Leigh, Ramus Susan J, Schildkraut Joellen M, Sellers Thomas A, Pharoah Paul D P
Abstract excerpt
In this review, we summarize current progress in the genetic epidemiology of epithelial ovarian cancer (EOC), focusing exclusively on elucidating the role of common germline genetic variation in conferring susceptibility to EOC. We provide an overview of the more than 30 EOC risk loci identified to date by genome-wide association studies (GWAS) and describe the contribution of large-scale, cross-cancer type,...
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