Article
Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines.
Human molecular genetics - 23 Aug 2022
Crouzier Lucie, Richard Elodie M, Diez Camille, Alzaeem Hala, Denus Morgane, Cubedo Nicolas, Delaunay Thomas, Glendenning Emily, Baxendale Sarah, Liévens Jean-Charles, Whitfield Tanya T, Maurice Tangui, Delprat Benjamin
Abstract excerpt
Wolfram syndrome (WS) is a rare genetic disease characterized by diabetes, optic atrophy and deafness. Patients die at 35 years of age, mainly from respiratory failure or dysphagia. Unfortunately, there is no treatment to block the progression of symptoms and there is an urgent need for adequate research models. Here, we report on the phenotypical characterization of two loss-of-function zebrafish mutant lines:...
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