Interrelationships between radiation-induced mutations and modifications in gene expression linked to cancer.

Abstract excerpt

Ionizing radiation induces cancer in humans, but the mechanisms are not established. One simple way by which radiation could induce cancer is by inducing a genetic mutation in one or more of the multiple steps in the oncogenic pathway. However, many investigators favor the hypothesis that a mutator phenotype is necessary for a single cell to acquire the multiple genetic changes found in cancer. The alternative...

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