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Detection of cell-free tumor DNA in cerebrospinal fluid as a diagnostic biomarker for leptomeningeal melanoma metastasis: A case series.

Pigment cell & melanoma research - 1 Nov 2024

Dirven Iris, Vounckx Manon, Kessels Jolien I, Lauwyck Justine, Awada Gil, Vanbinst Anne-Marie, Neyns Bart

Abstract excerpt

Leptomeningeal melanoma metastases (LMM) are associated with poor survival. Diagnosis is based on clinical presentation, brain MRI and cerebrospinal fluid (CSF) analysis. Inconclusive findings at initial presentation can delay treatment. In this single-center case series, detection of BRAFV600- and NRASQ61-mutant cell-free tumor DNA (cfDNA) in CSF was evaluated as a complementary diagnostic biomarker. In 12...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38990845
DOI: 10.1111/pcmr.13186

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