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Plasma exosomal HERV-K transcripts are increased in amyotrophic lateral sclerosis

2025-11-10

Abstract excerpt

Human endogenous retrovirus-K (HERV-K) reactivation is increasingly implicated in amyotrophic lateral sclerosis (ALS), with ongoing clinical trials investigating antiretroviral therapies. However, there is limited understanding of how HERV-K is trafficked in peripheral biofluids, and the role of exosomes, nano-sized extracellular vesicles , in this process remains largely unexplored. Exosomes offer a stable and c...

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Literature Corpus work
d7e9aa81-fcff-5e47-a14e-957357e8dbcf
DOI
10.1101/2025.11.07.686090
Open publication

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