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Article

Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

8 Nov 2010

Abstract excerpt

OBJECTIVE: Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motor neurons, of unknown etiology. Previous studies showed reverse transcriptase in serum of ALS patients at levels comparable to human immunodeficiency virus-infected patients; however, the source and significance of the retroviral elements is uncertain. METHODS: Expression of a human endogenous retrovirus (HERV-K) was...

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PMID: 21280084
DOI: 10.1002/ana.22149

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