Metabolic remodeling by RNA polymerase gene mutations is associated with reduced β-lactam susceptibility in oxacillin-susceptible MRSA.

doi:10.1128/mbio.00339-24

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Metabolic remodeling by RNA polymerase gene mutations is associated with reduced β-lactam susceptibility in oxacillin-susceptible MRSA.

mBio - 12 Jun 2024

Watanabe Shinya, Nsofor Chijioke A, Thitiananpakorn Kanate, Tan Xin-Ee, Aiba Yoshifumi, Takenouchi Remi, Kiga Kotaro, Sasahara Teppei, Miyanaga Kazuhiko, Veeranarayanan Srivani, Shimamori Yuzuki, Lian Adeline Yeo Syin, Nguyen Thuy Minh, Nguyen Huong Minh, Alessa Ola, Kumwenda Geoffrey Peterkins, Jayathilake Sarangi, Revilleza Jastin Edrian Cocuangco, Baranwal Priyanka, Nishikawa Yutaro, Li Feng-Yu, Kawaguchi Tomofumi, Sankaranarayanan Sowmiya, Arbaah Mahmoud, Zhang Yuancheng, Maniruzzaman, Liu Yi, Sarah Hossain, Li Junjie, Sugano Takashi, Ho Thi My Duyen, Batbold Anujin, Nayanjin Tergel, Cui Longzhu

Abstract excerpt

The emergence of oxacillin-susceptible methicillin-resistant Staphylococcus aureus (OS-MRSA) has imposed further challenges to the clinical management of MRSA infections. When exposed to β-lactam antibiotics, these strains can easily acquire reduced β-lactam susceptibility through chromosomal mutations, including those in RNA polymerase (RNAP) genes such as rpoBC, which may then lead to treatment failure. Despite...

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PMID: 38988221
DOI: 10.1128/mbio.00339-24
PMCID: PMC11237739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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