Article
Identification and characterization of mutations responsible for the β-lactam resistance in oxacillin-susceptible mecA-positive Staphylococcus aureus.
Scientific reports - 9 Oct 2020
Boonsiri Tanit, Watanabe Shinya, Tan Xin-Ee, Thitiananpakorn Kanate, Narimatsu Ryu, Sasaki Kosuke, Takenouchi Remi, Sato'o Yusuke, Aiba Yoshifumi, Kiga Kotaro, Sasahara Teppei, Taki Yusuke, Li Feng-Yu, Zhang Yuancheng, Azam Aa Haeruman, Kawaguchi Tomofumi, Cui Longzhu
Abstract excerpt
Staphylococcus aureus strains that are susceptible to the β-lactam antibiotic oxacillin despite carrying mecA (OS-MRSA) cause serious clinical problems globally because of their ability to easily acquire β-lactam resistance. Understanding the genetic mechanism(s) of acquisition of the resistance is therefore crucial for infection control management. For this purpose, a whole-genome sequencing-based analysis was...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- DNA-Directed RNA Polymerases
- Down-Regulation
- Gene Expression Regulation, Bacterial
- Genome
- Genome-Wide Association Study
- Humans