Article
Association of Body Mass Index and Parkinson Disease: A Bidirectional Mendelian Randomization Study.
Neurology - 13 Aug 2024
Domenighetti Cloé, Sugier Pierre-Emmanuel, Ashok Kumar Sreelatha Ashwin, Schulte Claudia, Grover Sandeep, Portugal Berta, Lee Pei-Chen, May Patrick, Bobbili Dheeraj, Radivojkov Blagojevic Milena, Lichtner Peter, Singleton Andrew B, Hernandez Dena, Edsall Connor, Mellick George D, Zimprich Alexander A, Pirker Walter, Rogaeva Ekaterina A, Lang Anthony E, Koks Sulev, Taba Pille, Lesage Suzanne, Brice Alexis, Corvol Jean-Christophe, Chartier-Harlin Marie-Christine, Mutez Eugenie, Brockmann Kathrin, Deutschlander Angela B, Hadjigeorgiou Georgios M, Dardiotis Efthimios, Stefanis Leonidas, Simitsi Athina Maria, Valente Enza Maria, Petrucci Simona, Straniero Letizia, Zecchinelli Anna L, Pezzoli Gianni, Brighina Laura, Ferrarese Carlo, Annesi Grazia, Quattrone Andrea, Gagliardi Monica, Matsuo Hirotaka, Nakayama Akiyoshi, Hattori Nobutaka, Nishioka Kenya, Chung Sun Ju, Kim Yun Joong, Kolber Pierre, Van De Warrenburg Bart P C, Bloem Bastiaan R, Toft Mathias, Pihlstrøm Lasse, Correia Guedes Leonor, Ferreira Joaquim J, Bardien Soraya, Carr Jonathan, Tolosa Eduardo, Ezquerra Mario, Pastor Pau, Diez-Fairen Monica, Wirdefeldt Karin, Pedersen Nancy L, Ran Caroline, Belin Andrea C, Puschmann Andreas, Hellberg Clara, Clarke Carl E, Morrison Karen E, Tan Manuela M, Krainc Dimitri, Burbulla Lena F, Farrer Matthew, Kruger Rejko, Gasser Thomas, Sharma Manu, Elbaz Alexis
Abstract excerpt
BACKGROUND AND OBJECTIVES: The role of body mass index (BMI) in Parkinson disease (PD) is unclear. Based on the Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in PD (Courage-PD) consortium, we used 2-sample Mendelian randomization (MR) to replicate a previously reported inverse association of genetically predicted BMI with PD and investigated whether findings were robust in analyses...
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