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Article

Hyperthyroidism Is Genetically Associated With Reduced Risk of Parkinson's Disease: A Mendelian Randomization Analysis.

The European journal of neuroscience - 1 Jul 2026

Luo Meng, Huang Shiren, Wang Wei

Abstract excerpt

Parkinson's disease (PD) is a progressive neurodegenerative disorder whose aetiology involves an intricate interplay of genetic, immune, metabolic and environmental factors. Endocrine dysfunction-particularly disturbances of thyroid hormone signalling-has been proposed as a contributor to neurodegeneration, but conventional observational studies have produced inconsistent results, and prior Mendelian...

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PMID: 42417582
DOI: 10.1111/ejn.70616
PMCID: PMC13344109

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