Article
Sex differences in neural projections of fear memory processing in mice and humans.
Science advances - 12 Jul 2024
Florido Antonio, Velasco Eric R, Romero Leire R, Acharya Neha, Marin Blasco Ignacio J, Nabás Jaime F, Perez-Caballero Laura, Rivero Guadalupe, Olabarrieta Estíbaliz, Nuñez-delMoral Amaia, González-Parra Jose A, Porta-Casteràs Daniel, Cano Marta, Steward Trevor, Antony Monica S, Cardoner Narcís, Torrubia Rafael, Jackson Alexander C, Fullana Miquel A, Andero Raül
Abstract excerpt
It remains unexplored in the field of fear memory whether functional neuronal connectivity between two brain areas is necessary for one sex but not the other. Here, we show that chemogenetic silencing of centromedial (CeM)-Tac2 fibers in the lateral posterior BNST (BNSTpl) decreased fear memory consolidation in male mice but not females. Optogenetic excitation of CeM-Tac2 fibers in the BNSTpl exhibited enhanced...
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