Article
Neural Mechanism of a Sex-Specific Risk Variant for Posttraumatic Stress Disorder in the Type I Receptor of the Pituitary Adenylate Cyclase Activating Polypeptide.
Biological psychiatry - 15 Dec 2015
Pohlack Sebastian T, Nees Frauke, Ruttorf Michaela, Cacciaglia Raffaele, Winkelmann Tobias, Schad Lothar R, Witt Stephanie H, Rietschel Marcella, Flor Herta
Abstract excerpt
BACKGROUND: Posttraumatic stress disorder (PTSD) is a frequent anxiety disorder with higher prevalence rates in female patients than in male patients (2.5:1). Association with a single nucleotide polymorphism (rs2267735) in the gene ADCYAP1R1 encoding the type I receptor (PAC1-R) of the pituitary adenylate cyclase activating polypeptide has been reported with PTSD in female patients. We sought to identify the...
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