Article

High RAD51 Gene Expression is Associated with Aggressive Biology and with Poor Survival in Breast Cancer

2021-12-21

Abstract excerpt

<title>Abstract</title> <p><bold>Purpose</bold>: Although DNA repair mechanism is a key to prevent carcinogenesis, its activation in established cancer cells may support their proliferation and aggravate cancer progression. RAD51 cooperates with BRCA2 and is essential in the homologous recombination of DNA repair. To this end, we hypothesized that RAD51 gene expression is associated with cancer cell proliferation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 42b94e20-f8ce-5d89-861c-f507392ce90e
DOI: 10.21203/rs.3.rs-1170225/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High RAD51 Gene Expression is Associated with Aggressive Biology and with Poor Survival in Breast CancerDOI 10.21203/rs.3.rs-1170225/v1Read

Comprehensive Analysis of Prognostic and Immune Infiltrates for RAD51 in Human Breast Cancer.Semantic proximity Read

Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response proteinSemantic proximity Read

Comprehensive Analysis of the Expression and Prognosis for RAD51 Family in Human Breast CancerSemantic proximity Read

A Pan-Cancer Bioinformatic Analysis of RAD51 Regarding the Values for Diagnosis, Prognosis, and Therapeutic PredictionSemantic proximity Read

RAD51 Is Implicated in DNA Damage, Chemoresistance and Immune Dysregulation in Solid TumorsSemantic proximity Read

Comprehensive Bioinformatics Investigation of RAD51C in Cervical Cancer: Expression, Prognostic Significance, DNA methylation, Immune Infiltration, Immune Checkpoint Correlation, and Functional Network AnalysisSemantic proximity Read

The Genetic Polymorphisms of DNA Repair Gene RAD51 and Their Role as a Predictive Biomarker for Breast Cancer Risk and Response to Radiotherapy in Iraqi Women.Semantic proximity Read

A multidimensional analysis of RAD1 as an immunological and prognostic biomarker in BRCASemantic proximity Read

RAD51 as a potential surrogate marker for DNA repair capacity in solid malignanciesSemantic proximity Read

High RAD51 mRNA expression characterize estrogen receptor‐positive/progesteron receptor‐negative breast cancer and is associated with patient's outcomeSemantic proximity Read

Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancerSemantic proximity Read

CtBP1 transactivates RAD51 and confers cisplatin resistance to breast cancer cellsSemantic proximity Read