Article
Impact of genomic and epigenomic alterations of multigene on a multicancer pedigree.
Cancer medicine - 1 Jul 2024
Gao Jingyu, Wu Yongzhang, Yu Jieming, Qiu Yinbin, Yi Tiantian, Luo Chaochao, Zhang Junxiao, Lu Gary, Li Xu, Xiong Fu, Wu Xuedong, Pan Xinghua
Abstract excerpt
BACKGROUND: Germline mutations have been identified in a small number of hereditary cancers, but the genetic predisposition for many familial cancers remains to be elucidated. METHODS: This study identified a Chinese pedigree that presented different cancers (breast cancer, BRCA; adenocarcinoma of the esophagogastric junction, AEG; and B-cell acute lymphoblastic leukemia, B-ALL) in each of the three generations....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.