Article
Circadian genes differentially affect tolerance to ethanol in Drosophila.
Alcoholism, clinical and experimental research - 1 Nov 2013
Pohl Jascha B, Ghezzi Alfredo, Lew Linda K, Robles Roseanna B, Cormack Lawrence, Atkinson Nigel S
Abstract excerpt
BACKGROUND: There is a strong relationship between circadian rhythms and ethanol (EtOH) responses. EtOH consumption has been shown to disrupt physiological and behavioral circadian rhythms in mammals (Alcohol Clin Exp Res 2005b, 29, 1550). The Drosophila central circadian pacemaker is composed of proteins encoded by the per, tim, cyc, and Clk genes. Using Drosophila mutant analysis, we asked whether these central...
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