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Article

A precise microdissection strategy enabled spatial heterogeneity analysis on the targeted region of formalin-fixed paraffin-embedded tissues.

Talanta - 1 Oct 2024

Chen Chen, Li Ying, Wei Wei, Lu Yin, Zou Bingjie, Zhang Likun, Shan Jingwen, Zhu Yue, Wang Shanshan, Wu Haiping, Su Hua, Zhou Guohua

Abstract excerpt

In recent years, the development of spatial transcriptomic technologies has enabled us to gain an in-depth understanding of the spatial heterogeneity of gene expression in biological tissues. However, a simple and efficient tool is required to analyze multiple spatial targets, such as mRNAs, miRNAs, or genetic mutations, at high resolution in formalin-fixed paraffin-embedded (FFPE) tissue sections. In this study,...

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Identifiers

PMID: 38963978
DOI: 10.1016/j.talanta.2024.126501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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