Article
CircCFL1 Promotes TNBC Stemness and Immunoescape via Deacetylation-Mediated c-Myc Deubiquitylation to Facilitate Mutant TP53 Transcription.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Sept 2024
Wang Zekun, Li Yaming, Yang Jingwen, Sun Yuhan, He Yinqiao, Wang Yuping, Liang Yiran, Chen Xi, Chen Tong, Han Dianwen, Zhang Ning, Chen Bing, Zhao Wenjing, Wang Lijuan, Luo Dan, Yang Qifeng
Abstract excerpt
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer. TP53, which has a mutation rate of ≈70%-80% in TNBC patients, plays oncogenic roles when mutated. However, whether circRNAs can exert their effects on TNBC through regulating mutant TP53 has not been well evaluated. In this study, circCFL1, which is highly expressed in TNBC cells and tissues and has prognostic potential is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.