Article
The benefits of permutation-based genome-wide association studies.
Journal of experimental botany - 11 Sept 2024
John Maura, Korte Arthur, Grimm Dominik G
Abstract excerpt
Linear mixed models (LMMs) are a commonly used method for genome-wide association studies (GWAS) that aim to detect associations between genetic markers and phenotypic measurements in a population of individuals while accounting for population structure and cryptic relatedness. In a standard GWAS, hundreds of thousands to millions of statistical tests are performed, requiring control for multiple hypothesis...
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