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Article

FlexLMM: a Nextflow linear mixed model framework for GWAS.

Bioinformatics (Oxford, England) - 26 Dec 2024

Pierotti Saul, Fitzgerald Tomas, Birney Ewan

Abstract excerpt

SUMMARY: Linear mixed models (LMMs) are a commonly used statistical approach in genome-wide association studies when population structure is present. However, naive permutations of the phenotype to empirically estimate the null distribution of a statistic of interest are not appropriate in the presence of population structure or covariates. This is because the samples are not exchangeable with each other under...

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Topics

Genome-Wide Association Study
Linear Models
Software
Humans
Animals
Polymorphism, Single Nucleotide
Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Algorithms

Models, Genetic

Source

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Identifiers

PMID: 39814073
DOI: 10.1093/bioinformatics/btaf021
PMCID: PMC11783306

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